Leukemogenesis: Small differences in Myb have large effects
نویسنده
چکیده
The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regulated.
منابع مشابه
Single Molecule Analysis of c-myb Alternative Splicing Reveals Novel Classifiers for Precursor B-ALL
The c-Myb transcription factor, a key regulator of proliferation and differentiation in hematopoietic and other cell types, has an N-terminal DNA binding domain and a large C-terminal domain responsible for transcriptional activation, negative regulation and determining target gene specificity. Overexpression and rearrangement of the c-myb gene (MYB) has been reported in some patients with leuk...
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عنوان ژورنال:
- Current Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1998